Axonal Guidance and Synaptogenesis

Development, plasticity and regeneration of neural circuits
Functional consequences of altered connectivity in schizophrenia; the early secretory pathway's role in neurodevelopment and synaptogenesis
Cellular and circuit mechanisms underlying drug addiction and sleep-mediated regulation of reward.
Regulation of GABAergic inhibition in development and mental disorders
Motoneuron development and spinal cord patterning.
Mouse models of developmental disorders.
Regulation and modulation of presynaptic ion channels and transmitter release in healthy and diseased synapses.
The goal of our research is to functionally dissect the neural circuits that underlie pain and itch.