Axonal Guidance and Synaptogenesis

Functional consequences of altered connectivity in schizophrenia; the early secretory pathway's role in neurodevelopment and synaptogenesis
Cellular and circuitry mechanisms underlying drug addiction and sleep regulation of reward.
Regulation of GABAergic inhibition in development and mental disorders
Neurite outgrowth and synaptogenesis.
Motoneuron development and spinal cord patterning.
CNS stem cells.
Regulation and modulation of presynaptic ion channels and transmitter release in healthy and diseased synapses.
Genetic analysis of vertebrate CNS development.
Cellular transplants for spinal cord repair. Development of combinatorial spinal cord repair strategies.
The goal of our research is to functionally dissect the neural circuits that underlie pain and itch.
Regenerative medicine approaches to protecting and repairing the retina and the optic nerve.