C. Edward Dixon, PhD

Professor, Neurological Surgery, Anesthesiology, Neurobiology, Physical Medicine & Rehabilitation

Contact

217 Hill Building
412-383-2188
F: 412-624-0943
dixonec@upmc.edu

Education

PhD, Virginia Commonwealth University (1985)

Focus

Mechanisms of post-traumatic memory deficits, models of traumatic brain injury, and functional outcomes.

Research Summary

Mechanisms of induction and recovery of functional deficits following traumatic brain injury; neurotransmitter agonist therapies for recovery of post traumatic functional deficits; models of traumatic brain injury; clinical studies of pharmacotherapy in TBI patients.

Publications

Carlson SW, Yan, HQ, Ma, M, li, Y, Henchir, J, Dixon CE. Traumatic Brain Injury Impairs SNARE Complex Formation and Alters Synaptic Vesicle Distribution in the Hippocampus, J Neurotrauma 33(1):113-121, 2016.
 
Smith DH, Hicks M, Johnson VE, Bergstrom D, Cummings D, Noble-Haeusslein L, Hovda D, Whalen M, Ahlers S, LaPlaca M, Tortella F, Duhaime AC, Dixon CE. Preclinical traumatic brain injury common data elements: Towards a common language across laboratories. J Neurotrauma 15;32(22):1725-35, 2015.
 
Bales JW, Wagner AK, Kline AE, Dixon CE. Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis. Neurosci Biobehav Rev 33:981-1003, 2009.

Yan, H.Q., Ma, X., Chen, X., Li, Y., Shao, L. and Dixon, C.E. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res 1134: 171-179, 2007.

Clark, R.S.B., Nathaniel, P.D., Zhang, X., Dixon, C.E., Alber, S.M., Watkins, S.C., Melick, J.A., Kochanek, P.M. and Graham, S.H. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 27: 316-326, 2007.

Kline, A.E., Massucci, J.L., Zafonte, R.D., Dixon, C.E., Defeo, J.R. and Rogers, E.H. Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma. Crit Care Med 35(3): 919-924, 2007.

Wagner, A.K., Ren, D., Conley, Y.P., Ma, X., Kerr, M.E., Zafonte, R.D., Puccio, A.M., Marion, D.W. and Dixon, C.E. Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury. J Neurosurg 106: 538-547, 2007.

Clark, R., Vagni, V., Nathaniel, P., Jenkins, L., Dixon, C.E. and Szabo, C. Local administration of the poly-ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma 2007 (in press).