Dean F. Salisbury, PhD

Professor, Psychiatry

Focus

Human cognitive neuroscience and multimodal neuroimaging of pathology and pathophysiology in the early course of psychosis

Research Summary

The Clinical Neurophysiology Research Laboratory’s program of research focuses on understanding the pathology and pathophysiology of first episode psychosis and the progressive course of structural and functional impairments early in disease course. Understanding of the basic dysfunctions will, in turn, lead to earlier identification, better interventions, and improved outcome in schizophrenia and other psychotic disorders. The objectives of this work are to: 1) Understand the brain abnormalities that give rise to psychosis by focusing on structural and functional abnormalities that can be tied to specific symptom constellations; 2) Track progressive changes in brain structure and function during the early disease course and relate such changes to the evolution and trajectory of clinical symptoms; 3) Develop simple to administer neurophysiological tests for deployment into clinical high risk samples as biomarkers of psychosis; and 4) Develop translational measures of simple cognitive and sensory processes that can be applied to animal models to understand the basic underlying cortical circuitry. Dr Salisbury’s laboratory utilizes multimodal imaging of neurophysiology (EEG, MEG), hemodynamics (MRI), and anatomy (MRI) in service of realizing these objectives by capitalizing on the outstanding infrastructure for integrated clinical care and research studies for first episode psychosis at WPIC.

 

Summer Undergraduate Research Program

Yes

Publications

Salisbury DF, Polizzotto NR, Nestor PG, Haigh SM, Koehler J, & McCarley RW. (2016). Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum. Schizophrenia Bulletin, sbw074. http://schizophreniabulletin.oxfordjournals.org/content/early/2016/05/26/schbul.sbw074.full.pdf+html

Haigh SM, Coffman BA, Murphy TK, Butera CD, & Salisbury DF. (2016). Abnormal auditory pattern perception in schizophrenia. Schizophrenia Research, 176:473-479. http://www.sciencedirect.com/science/article/pii/S0920996416303231

Teichert T, Gurnsey K, Salisbury D, & Sweet RA. (2016). Contextual processing in unpredictable auditory environments: the limited resource model of auditory refractoriness in the rhesus. Journal of Neurophysiology, 116:2125-2139. http://jn.physiology.org/content/116/5/2125.abstract

Lee SH, Niznikiewicz M, Asami T, Otsuka T, Salisbury DF, Shenton ME, McCarley RW. (2016). Initial and Progressive Gray Matter Abnormalities in Insular Gyrus and Temporal Pole in First-Episode Schizophrenia Contrasted with First-Episode Affective Psychosis. Schizophrenia Bulletin, 42:790-801. http://schizophreniabulletin.oxfordjournals.org/content/42/3/790

Salisbury DF & McCathern AG. (2016). Abnormal complex auditory pattern analysis in schizophrenia reflected in an absent missing stimulus mismatch negativity. Brain Topography, 29:867-874. http://link.springer.com/article/10.1007/s10548-016-0514-2