Kejie Yin, MD, PhD

Assistant Professor, Neurology

Contact

S-514 BSTWR
412-383-6038
F: 412-648-8081
yink2@upmc.edu

Education

MD, Yangzhou University Medical College (1983)
PhD, Fudan University Shanghai Medical College (1998)

Focus

Mechanisms of neurovascular damage and repair in cerebral ischemia and traumatic brain injury

Research Summary

Dr. Yin’s research interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural dysfunction after ischemic stroke and traumatic brain injury by using state-of-the-art cell biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal approaches. Currently, major ongoing research activities in Dr. Yin’s laboratory focus on investigating how non-coding RNAs (microRNAs, long non-coding RNAs) and Krüppel-like transcription factors regulate neurovascular pathophysiology (Blood-Brain Barrier disruption, Vascular and parenchymal inflammation, Angiogenesis, etc.), affect neurological outcomes, and modulate brain repair and functional recovery after ischemic stroke and traumatic brain injury. The long-term research goal of Dr. Yin’s laboratory is to discover novel molecular or pharmaceutical targets for the development of effective vaso-/neuro-protective or neurorestorative therapies against ischemic stroke and traumatic brain injury.

 

Summer Undergraduate Research Program

Yes

Publications

Yin KJ, Deng Z, Hamblin M, Huang HR, Xiang Y, Zhang JF, Wang YZ, Chen YE. PPARδ regulation of miR-15a in ischemia-induced vascular endothelial injury.  Journal of Neuroscience 2010; 30(18):6398-6408

Yin KJ, Deng Z, Huang HR, Hamblin M, Xie CQ, Zhang JF, Chen YE. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia.  Neurobiology of Disease 2010; 38:17-26

Yin KJ, Deng Z, Hamblin M, Zhang JF, Chen YE. Vascular PPARδ protects against stroke-induced brain injury. Arteriosclerosis, Thrombosis, and Vascular Biology 2011; 31(3):574-81

Yin KJ, Olson K, Hamblin M, Zhang JF, Schwendeman SP, Chen YE. Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. Journal of Biological Chemistry 2012; 287(32): 27055-27064

Yin KJ, Fan YB, Hamblin M, Zhang JF, Li S, Hawse JR, Subramaniam M, Song CZ, Urrutia R, Lin JD, Chen YE. KLF11 mediates PPAR cerebrovascular protection in ischemic stroke. Brain 2013; 136:1274-1287

Yin KJ, Hamblin M, Zhang J, Chen YE. Non-coding RNAs and cerebrovascular endothelial pathophysiology in stroke. Neurochemistry International 2014; 77:9-16

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ.  Altered Long Non-coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.  Experimental Neurology 2016; 277:162-70.

Tang X, Liu K, Hamblin MH, Yin KJ.  Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic brain injury. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0556-9. [Epub ahead of print]

Yang X, Liu K, Hamblin MH, Steller A, Chen J, Yin KJ.  MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 2017; 48(7):1941-1947

Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ.  Long Non-coding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 2017; 37(7):1797-1806.