Yan Dong, PhD

Assistant Professor, Neuroscience

Contact

269 Crawford Hall
F: 412-624-9198
yandong@pitt.edu
Website >

Education

PhD, The Chicago Medical School (2014)

Focus

Cellular and circuitry mechanisms underlying pathological neural plasticity

Research Summary

Emotion and motivation are two basic, interlinked concepts in neuroscience, with ramifying connotations across psychology and philosophy. Thus far, neuroscience cannot yet provide coherent explanations for why some stimuli cheer us up whereas others make us sad, why my fishing trip to a picturesque river is given up in favor of typing this paragraph, and why reading and memorizing knowledge that used to be so boring for me as a kid become so rewarding after a 20-year of "habituation".

Our long-term research goal is to understand the neural mechanisms underlying emotional and motivational responses. We focus on animal models related to drug addiction. Addictive drugs are among the most effective and efficient external stimuli that evoke the strongest emotional and motivational states. Once "hijacked" into the addictive state, an individual will be primarily motivated by an exceedingly strong emotional state, the drug-seeking/craving state.

We hypothesize that strong incentive stimuli, such as experience of drugs of abuse, shift the emotional and motivational states by rewiring the neural circuits in the brain reward pathway. To test this hypothesis, we have been examining several novel forms of neural plasticity upon exposure to cocaine.

Two related research areas are depression, which is characterized in part as a lack of motivation, and sleep, which modulates the emotional and motivational state across most species.

These lines of research in the laboratory are currently carried out by several highly motivated young souls, who are equipped with a combination of molecular, cellular, electrophysiological, and behavioral expertise.

Publications

Graziane NM, Sun S, Wright WJ, Jang D, Liu Z, Huang YH, Nestler EJ, Wang YT, Schlüter OM, Dong Y.
Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses.
Nat Neurosci. 2016 May 30. doi: 10.1038/nn.4313. [Epub ahead of print]
 
Ma YY, Wang X, Huang Y, Marie H, Nestler EJ, Schlüter OM, Dong Y. Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5089-94. doi: 10.1073/pnas.1524739113. 
 
Neumann PA, Wang Y, Yan Y, Wang Y, Ishikawa M, Cui R, Huang YH, Sesack SR, Schlüter OM, Dong Y. Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection. Neuropsychopharmacology. 2016 Apr 14. doi: 10.1038/npp.2016.52.
 
Chen B, Wang Y, Liu X, Liu Z, Dong Y, Huang YH. Sleep Regulates Incubation of Cocaine Craving. J Neurosci. 2015 Sep 30;35(39):13300-10. doi: 10.1523/JNEUROSCI.1065-15.2015.
 
Huang YH, Schlüter OM, Dong Y. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction. Neuroscientist. 2015 Oct;21(5):451-9. doi: 10.1177/1073858415579405. Epub 2015 Mar 31.

Ishikawa, M., Otaka, M., Huang, Y.H., Neumann, P.A., Winters, B.D., Grace, A.A., SchlŸter, O.M., Dong, Y. Dopamine triggers Heterosynaptic Plasticity. Journal of Neuroscience. 33(16):6759-6765, 2013.

Otaka, M., Ishikawa, M., Lee, B.R., Liu, L., Neumann, P.A., Cui, R., Huang, Y.H., SchlŸter, O.M., Dong, Y. Exposure to Cocaine Regulates Inhibitory Synaptic Transmission in the Nucleus Accumbens. Journal of Neuroscience. Featured Article. 33(16): 6753-6758, 2013.

Suska,, A., Lee, B.R., Huang, Y.H., Dong, Y., SchlŸter, O.M. Presynaptic enhancement of glutamatergic transmission within the nucleus accumbens following cocaine exposure. Proc Natl Acad Sci USA. 110(2): 713-8, 2013.