Changes in sensory neurons are thought to contribute to pain associated with complex disorders including pancreatitis and cancer. Importantly, altered sensory neurons can directly contribute to the disease process itself. In addition to debilitating sensory deficits such as pain, recent studies suggest that dysregulated sensory neuron signaling directly alters progression of multiple diseases including cancer. The research in the Saloman laboratory utilizes anatomical, behavioral, optogenetics, calcium imaging as well as traditional cellular and molecular techniques to elucidate the role of the peripheral nervous system in regulating homeostasis as well as pathological conditions, including pain, pancreatitis and tumorigenesis.
Saloman JL, Cohen JA, Kaplan DH. Intimate neuro-immune interactions: Breaking barriers between systems to make meaningful progress. Current Opinion in Neurobiology. 2019 Dec;62:
Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 Jul;48(6):759-779. PMID: 31206467.
Saloman JL, Singhi AD, Hartman DJ, Normolle DP, Albers KM, Davis BM. Systemic depletion of nerve growth factors inhibits disease progression in a genetically engineered model of Pancreatic Ductal Adenocarcinoma. Pancreas 2018 Aug; 47(7):856-863. Pubmed PMID: 29975347.
Saloman JL, Scheff NN, Snyder LM, Ross SE, Gold MS, Davis BM. Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-independent Functional Changes in Sensory Neurons. J Neurosci. 2016 Oct 19; 36(42): 0769-10781. Pubmed PMID: 27798132.
Saloman JL, Albers KM, Hartmann DJ, Li D, Crawford HC, Muha EA, Rhim AD, Davis BM. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of tumorigenesis. PNAS. 2016 Mar 15; 113(11): 3078-3083. Pubmed PMID: 26929329.