Dean F. Salisbury, PhD

  • Professor, Psychiatry

Phone

Phone: N/A

E-mail

salisburyd@upmc.edu

Location

3811 O'Hara St

Research Interest Summary

Human cognitive neuroscience and multimodal neuroimaging of pathology and pathophysiology in the early course of psychosis

The Clinical Neurophysiology Research Laboratory’s program of research focuses on understanding the pathology and pathophysiology of first episode psychosis and the progressive course of structural and functional impairments early in disease course. Understanding of the basic dysfunctions will, in turn, lead to earlier identification, better interventions, and improved outcome in schizophrenia and other psychotic disorders. The objectives of this work are to: 1) Understand the brain abnormalities that give rise to psychosis by focusing on structural and functional abnormalities that can be tied to specific symptom constellations; 2) Track progressive changes in brain structure and function during the early disease course and relate such changes to the evolution and trajectory of clinical symptoms; 3) Develop simple to administer neurophysiological tests for deployment into clinical high risk samples as biomarkers of psychosis; and 4) Develop translational measures of simple cognitive and sensory processes that can be applied to animal models to understand the basic underlying cortical circuitry. Dr Salisbury’s laboratory utilizes multimodal imaging of neurophysiology (EEG, MEG), hemodynamics (MRI), and anatomy (MRI) in service of realizing these objectives by capitalizing on the outstanding infrastructure for integrated clinical care and research studies for first episode psychosis at WPIC.

Phalen H, Coffman BA, Ghuman A, Sejdić E, Salisbury DF. (2019). Non-negative Matrix Factorization Reveals Resting-State Cortical Alpha Network Abnormalities in the First-Episode Schizophrenia Spectrum. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 31451387 DOI: 10.1016/j.bpsc.2019.06.010 

 

Salisbury DF, Kohler J, Shenton MEMcCarley RW. (2019). Deficit Effect Sizes and Correlations of Auditory Event-Related Potentials at First Hospitalization in the Schizophrenia Spectrum. Clinical Eeg and Neuroscience. 1550059419868115. PMID 31390901 DOI: 10.1177/1550059419868115 

 

Haigh SM, Laher RM, Murphy TK, Coffman BA, Ward KL, Leiter-McBeth JR, Holt LLSalisbury DF. (2019). Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia. Schizophrenia Research. PMID 30982643 DOI: 10.1016/j.schres.2019.03.028 

 

Haigh SM, Coffman BA, Murphy TK, Butera CD, Leiter-McBeth JR, Salisbury DF. (2018). Reduced late mismatch negativity and auditory sustained potential to rule-based patterns in schizophrenia. The European Journal of Neuroscience. PMID 30471147 DOI: 10.1111/ejn.14274 

 

Ohtani T, Del Re E, Levitt JJ, Niznikiewicz M, Konishi J, Asami T, Kawashima T, Roppongi T, Nestor PGShenton MESalisbury DFMcCarley RW. (2018). Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis. Brain Structure & Function. PMID 29671056 DOI: 10.1007/s00429-018-1634-0 

 

Coffman BA, Haigh SM, Murphy TK, Leiter-Mcbeth J, Salisbury DF. (2017). Reduced auditory segmentation potentials in first-episode schizophrenia. Schizophrenia Research. PMID 29070441 DOI: 10.1016/j.schres.2017.10.011 

 

Salisbury DF, Polizzotto NR, Nestor PG, Haigh SM, Koehler J, & McCarley RW. (2016). Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum. Schizophrenia Bulletin, sbw074. http://schizophreniabulletin.oxfordjournals.org/content/early/2016/05/26/schbul.sbw074.full.pdf+html

 

Haigh SM, Coffman BA, Murphy TK, Butera CD, & Salisbury DF. (2016). Abnormal auditory pattern perception in schizophrenia. Schizophrenia Research, 176:473-479. http://www.sciencedirect.com/science/article/pii/S0920996416303231

 

Teichert T, Gurnsey K, Salisbury D, & Sweet RA. (2016). Contextual processing in unpredictable auditory environments: the limited resource model of auditory refractoriness in the rhesus. Journal of Neurophysiology, 116:2125-2139. http://jn.physiology.org/content/116/5/2125.abstract

 

Lee SH, Niznikiewicz M, Asami T, Otsuka T, Salisbury DF, Shenton ME, McCarley RW. (2016). Initial and Progressive Gray Matter Abnormalities in Insular Gyrus and Temporal Pole in First-Episode Schizophrenia Contrasted with First-Episode Affective Psychosis. Schizophrenia Bulletin, 42:790-801. http://schizophreniabulletin.oxfordjournals.org/content/42/3/790

 

Salisbury DF & McCathern AG. (2016). Abnormal complex auditory pattern analysis in schizophrenia reflected in an absent missing stimulus mismatch negativity. Brain Topography, 29:867-874. http://link.springer.com/article/10.1007/s10548-016-0514-2